| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5963321 | International Journal of Cardiology | 2016 | 4 Pages |
â¢Ventricular remodeling is a mechanism of heart failure.â¢Expression of miRNA in cardiomyocytes differ under different diseases.â¢miRNA may be a novel tool in diagnosis and therapy of heart failure.
Heart failure is the end stage of most cardiac diseases and also an important cardiovascular disease. Ventricular remodeling, a complicated pathophysiological process involving multiple molecular pathways, is a crucial mechanism for the occurrence and development of heart failure. A microRNA (miRNA) is a highly conservative noncoding molecule containing 18-25 nucleotides. miRNA is different from other RNAs. It mainly serves as an endogenous gene-regulating factor, and is a member of the complex regulatory network. It induces gene repression of target transcripts by affecting mRNA at the post-transcriptional level Vasudevan et al. (2007) . This study aimed at determining the mechanism of miRNA action in heart failure.
