Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5971511 | International Journal of Cardiology | 2014 | 8 Pages |
â¢Pericardial fat (PF) correlates with atrial fibrillation (AF) and its progression.â¢Complex fractionated atrial electrogram (CFAE) also correlates with AF progression.â¢PF significantly correlates with the area of CFAE.â¢PF is directly related to the genesis of CFAE, resulting in the development of AF.
Background/ObjectivesPericardial fat (PF) and complex fractionated atrial electrogram (CFAE) are both associated with atrial fibrillation (AF). Therefore, we examined the relation between PF and CFAE area in AF.MethodsThe study population included 120 control patients without AF and 120 patients with AF (80 paroxysmal AF and 40 persistent AF) who underwent catheter ablation. Total cardiac PF volume, representing all adipose tissue within the pericardial sac, was measured by contrast-enhanced computed tomography. The location and distribution of CFAE region were identified by left atrial endocardial mapping using a three-dimensional mapping system. We analyzed the significance of total cardiac PF volume and total area of CFAE region on AF, persistence of AF from paroxysmal to persistent form, and the relation between total cardiac PF volume and total CFAE area. We also evaluated the regional distribution of PF volume and CFAE area in five areas of the left atrium (LA).ResultsTotal cardiac PF volume correlated with AF (odds ratio [OR]: 1.024, p < 0.001). Total cardiac PF volume and total CFAE area were both independently associated with persistence of AF (OR: 1.018, p = 0.018, OR: 1.144, p = 0.002, respectively). Multivariate linear regression analysis identified total cardiac PF volume as a significant and independent determinant of total CFAE area (r = 0.488, p < 0.001). Furthermore, regional PF volume correlated with local CFAE area in an each LA area.ConclusionsPF volume correlated significantly with CFAE area in patients with AF. This finding suggests that PF is directly related to the progression of CFAE area and promotes the pathogenic process of AF.