Article ID Journal Published Year Pages File Type
5971756 International Journal of Cardiology 2014 13 Pages PDF
Abstract

ObjectivesThe analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary OCT images.MethodsWe studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically-indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm was also applied. Using certain lumen size and lumen shape characteristics, the fully- and semi-automated segmentation algorithms were validated over manual segmentation, which was considered as the gold standard.ResultsLinear regression and Bland-Altman analysis demonstrated that both the fully-automated and semi-automated segmentation had a very high agreement with the manual segmentation, with the semi-automated approach being slightly more accurate than the fully-automated method. The fully-automated and semi-automated OCT segmentation reduced the analysis time by more than 97% and 86%, respectively, compared to manual segmentation.ConclusionsIn the current work we validated a fully-automated OCT segmentation algorithm, as well as a semi-automated variation of it in an extensive “real-life” dataset of OCT images. The study showed that our algorithm can perform rapid and reliable segmentation of OCT images.

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