Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5973660 | International Journal of Cardiology | 2013 | 4 Pages |
BackgroundAnemia in heart failure patients and has been associated with increased morbi-mortality. Previous studies have treated anemia in heart failure patients with either erythropoietin alone or combination of erythropoietin and intravenous (IV) iron. However, the effect of IV or oral (PO) iron supplementation alone in heart failure patients with anemia was virtually unknown.AimTo compare, in a double-blind design, the effects of IV iron versus PO iron in anemic heart failure patients.MethodsIRON-HF study was a multicenter, investigator initiated, randomized, double-blind, placebo controlled trial that enrolled anemic heart failure patients with preserved renal function, low transferrin saturation (TSat) and low-to-moderately elevated ferritin levels. Interventions were Iron Sucrose IV 200Â mg, once a week, for 5Â weeks, ferrous sulfate 200Â mg PO TID, for 8Â weeks, or placebo. Primary endpoint was variation of peak oxygen consumption (peak VO2) assessed by ergospirometry over 3Â month follow-up.ResultsEighteen patients had full follow-up data. There was an increment of 3.5Â ml/kg/min in peak VO2 in the IV iron group. There was no increment in peak VO2 in the PO iron group. Patients' ferritin and TSat increased significantly in both treated groups. Hemoglobin increased similarly in all groups.ConclusionIV iron seems to be superior in improving functional capacity of heart failure patients. However, correction of anemia seems to be at least similar between PO iron and IV iron supplementation.