Intracoronary adiponectin levels rapidly and significantly increase after coronary revascularization

BackgroundWhether intracoronary plasma adiponectin levels may vary in the presence of coronary artery disease and change after coronary revascularization is unexplored.AimWe evaluated plasma adiponectin levels in peripheral vein and coronary circulation before and after coronary artery bypass graft (CABG) in patients with CAD and without CAD (no CAD).MethodsWe examined 12 patients with CAD who required CABG and 10 patients with non-CAD who underwent cardiac surgery for valve replacement. Peripheral plasma adiponectin and intracoronary adiponectin levels were measured in left coronary artery (LCA) and great cardiac vein (GCV) during coronary angiography at baseline, 24 h and 7 days after cardiac surgery.ResultsPeripheral and GCV and LCA plasma adiponectin levels were significantly lower in CAD than non-CAD patients (6 ± 3 vs 12 ± 5, p < 0.01; 6.1 ± 3 vs 10.6 ± 5, p < 0.05; 5.6 ± 2.7 vs 13 ± 6 μg/mL, p < 0.01, respectively). Peripheral and GCV and LCA plasma adiponectin levels significantly increased 7 days after CABG from 6 ± 3 to 9.7 ± 5 μg/mL, p < 0.05; 6.1 ± 3 to 9.6 ± 5, p < 0.05; 5.6 ± 2 to 9.2 ± 3 μg/mL, p < 0.01, respectively.ConclusionsOur study shows that intracoronary plasma adiponectin is lower in CAD than in no CAD subjects, but rapidly and significantly increases after CABG.