| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 598829 | Colloids and Surfaces B: Biointerfaces | 2016 | 8 Pages |
•A tri-block copolymer, PEG-PLA-PEG with a functional group was developed.•Animal model for metastatic cancer to bone and brain was developed.•Dox loading micelles showed the high efficiency of targeting in vivo.•Dox loading micelles suppressed metastatic tumor growth in bone and brain of mice.•The therapeutic efficacy was monitored by bioluminescence images.
We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideA nanomedicine based on a biocompatible poly(ethylene glycol)-poly(lactic acid)-poly(ethylene glycol) (PEG-PLA-PEG) was developed to escalate therapeutic efficacy of doxorubicin by enhanced targeting to metastatic breast cancers.
