| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5988317 | The Journal of Thoracic and Cardiovascular Surgery | 2016 | 9 Pages |
Abstract
Two grams of cefazolin at induction of anesthesia with a repeat dose after initiation of CPB ensures adequate drug levels to target a majority of pathogens of surgical site infections. Pharmacokinetic modeling demonstrated a significant influence of CPB on the volume of distribution and elimination of cefazolin. Other influences on pharmacokinetic parameters were albumin, protein, and creatinine clearance.
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Authors
Christian MD, Dagmar Horn, Swantje PhD, Georg PhD, Manfred PhD, Henryk MD, Robin MD, Bjoern MD,