Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5993013 | Journal of Vascular Surgery | 2016 | 11 Pages |
Abstract
Intimal hyperplasia is a major obstacle to patency after vein grafting. Although various treatments have been tested, a standard clinical treatment for intimal hyperplasia remains elusive. Here, in a rabbit model, long-term systemic administration of vildagliptin improved endothelial function, increased nitric oxide release, and reduced intimal hyperplasia in vein grafts. Our results support that dipeptidyl peptidase 4 inhibition is beneficial by limiting intimal hyperplasia in vein grafts.
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Authors
Akio MD, Kimihiro MD, PhD, Ryo RPT, Ms, Junko PhD, Takeo PhD,