| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 599346 | Colloids and Surfaces B: Biointerfaces | 2015 | 9 Pages |
•Drug-loaded PVDF fibrous membranes were fabricated by an electrospinning process.•The PVDF fibrous membranes owned excellent mechanical properties which was good for handling and replacement.•The drug-loaded fibrous membranes showed a suitable release behaviour for enrofloxacin (Enro) drugs.•The drug-loaded PVDF fibrous membranes were biocompatible and displayed excellent antibacterial activity.
The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12 h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing.
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