| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 599522 | Colloids and Surfaces B: Biointerfaces | 2014 | 9 Pages |
Abstract
- Didanosine-loaded microparticles were obtained by spray-drying to prevent drug degradation during gastric transit.
- The encapsulation efficiency ranged from 60 to 100%.
- The yield was up to 65%.
- The particles released the drug within 120Â min (in vitro release assays).
- Oral administration to rats increased 2.5-fold the oral bioavailability with respect to a ddI aqueous solution.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Katia P. Seremeta, MarÃa I. Reyes Tur, Sandra MartÃnez Pérez, Christian Höcht, Carlos Taira, Orestes D. López Hernández, Alejandro Sosnik,