| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 599532 | Colloids and Surfaces B: Biointerfaces | 2014 | 10 Pages |
Abstract
- A novel alendronate-hyaluronic acid (AL-HA) graft polymer was synthesized by amide coupling.
- AL-HA graft polymer was assembled over irinotecan containing NLC by calcium assisted mineralization.
- Low IC50 values and enhanced uptake was found in P-gp overexpressing MDR cells.
- In vitro targeting CD-44 bio-receptor in HT-29 and Colo-320 cells.
- Modulation of ATPase pump and MDR1 gene expression in cancer cell lines.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Lalit Mohan Negi, Sushama Talegaonkar, Manu Jaggi, Anita Kamra Verma, Ritu Verma, Sheetal Dobhal, Vijay Kumar,