Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5996950 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2013 | 7 Pages |
ObjectiveTo assess the accuracy of first trimester soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) in predicting pregnancy hypertension and pre-eclampsia; and compare with the accuracy of routinely collected maternal and clinical risk factors.Study designIn this population-based cohort study, serum sFlt-1 and PlGF levels were measured in first trimester in 2,681 women with singleton pregnancies in New South Wales, Australia.Main outcome measuresPrediction of pregnancy hypertension and pre-eclampsia.ResultsThere were 213 (7.9%) women with pregnancy hypertension, including 68 (2.5%) with pre-eclampsia. The area under the curve (AUC) for both sFlt-1 and PlGF was not different from chance, but combined was 0.55 (PÂ =Â 0.005). Parity and previous diagnosed hypertension had better predictive accuracy than serum biomarkers (AUCÂ =Â 0.64, PÂ <Â 0.001) and the predictive accuracy for all maternal and clinical information was fair (AUCÂ =Â 0.70, PÂ <Â 0.001 for pregnancy hypertension and AUCÂ =Â 0.74, PÂ <Â 0.001 for pre-eclampsia). Adding sFlt-1 and PlGF to maternal risk factors did not improve the ability of the models to predict pregnancy hypertension or pre-eclampsia.ConclusionsMaternal first trimester serum concentrations of sFlt-1 and PlGF do not predict hypertensive disorders in pregnancy any better than routinely collected clinical and maternal risk factor information. Screening for sFlt-1 and PlGF levels in early pregnancy would not identify those pregnancies at-risk.