| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 599734 | Colloids and Surfaces B: Biointerfaces | 2014 | 7 Pages |
•We have successfully prepared and characterized a group of triclosan-loaded carboxyl-terminated PAMAM dendrimers.•The dendrimer can induce in situ remineralization on the dentine and release anti-bacterial drug for local treatment at the same time.•The newly generated crystals are similar to the natural dentine in terms of shape, size and orientation degree.•This system is proved to be low cytotoxicity by MTT assay.•The drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree.
In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (HA) on etched dentine, and the regenerated HA has a similar crystal structure with natural dentine. It can also release the encapsulated triclosan for a long period. The interesting drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree, which are ideal to obtain multifunctional properties of long-term release of anti-bacterial drug for local treatment during the remineralization process. The triclosan-loaded G4-COOH provides a general strategy to cure dental caries and repair damaged dentine at the same time, which forms a potential restorative material for dental repair.
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