| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 599749 | Colloids and Surfaces B: Biointerfaces | 2014 | 10 Pages |
•PEG-poly(amine-co-ester) block copolymers were enzymatically synthesized in one step.•The copolymers formed stable micelle nanoparticles in aqueous medium with pH of 7.4.•At acidic pH, the micelles swelled substantially due to protonation of the micelle cores.•The drug-loaded micelles had a significantly higher drug release rate at pH of 5.0 vs. 7.4.•Both pH and the polymer composition control the rate of drug release from the micelles.
A series of PEGylated poly(amine-co-ester) terpolymers were successfully synthesized in one step via lipase-catalyzed copolymerization of ω-pentadecalactone (PDL), diethyl sebacate (DES), and N-methyldiethanolamine (MDEA) comonomers in the presence of poly(ethylene glycol) methyl ether as a chain-terminating agent. The resultant amphiphilic poly(ethylene glycol)-poly(PDL-co-MDEA-co-sebacate) (PEG-PPMS) block copolymers consisted of hydrophilic PEG chain segments and hydrophobic random PPMS chain segments, which self-assembled in aqueous medium to form stable, nanosized micelles at physiological pH of 7.4. Upon decreasing the medium pH from 7.4 to 5.0, the copolymer micelles swell significantly due to protonation of the amino groups in the micelle PPMS cores. Correspondingly, docetaxel (DTX)-encapsulated PEG2K-PPMS copolymer micelles showed gradual sustained drug release at pH of 7.4, but remarkably accelerated DTX release at acidic pH of 5.0. The drug-loaded micelle particles were readily internalized by SK-BR-3 cancer cells and, compared to free DTX drug, DTX-loaded micelles of the copolymers with optimal compositions exhibited enhanced potency against the cells. Biodegradable PEG-PPMS copolymer micelles represent a new type of promising, pH-responsive nanocarriers for anticancer drug delivery, and the drug release rate from the micelles can be systematically controlled by both pH and the copolymer composition.
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