| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 600023 | Colloids and Surfaces B: Biointerfaces | 2013 | 5 Pages |
A model has been developed for the determination of the correct absolute size of nanoparticles using a disc centrifuge; the method does not require externally measured or literature derived particle densities. The principle of this method is the altered settling velocity of particles in fluids with different viscosities and/or densities, with the use of a linear regression analysis for the calculation of particle densities. This allows a fast particle density determination with at least two measurements using a disc centrifuge and a small subset of easily measurable parameters. Furthermore, correctness of the model is evaluated using viruses and nonbiological particles of known densities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Size determination by disc centrifugation is a common method. ► Buoyant density is needed for correct size determination. ► A model for the density determination using the disc centrifuge was derived. ► Model was validated with several particles, including anorganic and virus particles.
