Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6000445 | Thrombosis Research | 2016 | 7 Pages |
â¢The Wells rule for DVT is often incorrectly used, mainly due to its length.â¢The I-DVT score is a simple and objective score consisting of four variables.â¢The simple I-DVT score and Wells rule have comparable diagnostic accuracy.â¢Safety and efficiency of the I-DVT score has to be further evaluated.
IntroductionThe Wells rule is the recommended first step in the work-up of suspected deep vein thrombosis (DVT). However, it is often incorrectly used leading to an excessive number of diagnostic tests used in daily practice and diagnostic failures. A simpler objective risk stratification tool may improve adherence to the guidelines. We evaluated the diagnostic performance of the I-DVT score, which consists of four easy assessable variables: Immobilization, > 3 cm Difference in calve circumferences, prior Venous thromboembolism (VTE) and active malignant Tumor.MethodsWe performed an observational study in 617 consecutive patients with suspected DVT. All patients were managed according to the recommended algorithm starting with the Wells rule followed by D-dimer test and/or compression ultrasonography (CUS). The I-DVT score was prospectively calculated at baseline and evaluated post-hoc.ResultsThe DVT prevalence was 36%. DVT could be excluded in 13% of patients without CUS by the Wells rule and a normal D-dimer test, with a 3-month VTE incidence of 1.2% (95%CI 0.03-6.5%). Using the I-DVT score, DVT would have been excluded in 9.1% of patients without additional CUS, with a 3-month VTE incidence of 0% (95%CI 0.0-6.4%). The area under the ROC curve (AUC) was 0.70 (95%CI 0.66-0.74) and 0.65 (95%CI 0.61-0.70) for the Wells rule and I-DVT score respectively (difference 0.049, 95%CI â 0.01-0.11; p = 0.13).ConclusionsThe simple I-DVT score and Wells rule have comparable diagnostic accuracy. It's safety, efficiency and associated potential improvement of guideline adherence in clinical practice has to be further evaluated in a prospective management study.