Article ID Journal Published Year Pages File Type
600057 Colloids and Surfaces B: Biointerfaces 2013 8 Pages PDF
Abstract

The current investigation deals with the development and optimization of oil-entrapped sterculia gum–alginate buoyant beads containing aceclofenac by ionotropic emulsion–gelation technique using 32 factorial design. The effect of polymer to drug ratio and sodium alginate to sterculia gum ratio on the drug entrapment efficiency (%), and cumulative drug release after 7 h (%) was optimized. The optimized oil-entrapped sterculia gum–alginate buoyant beads containing aceclofenac (F-O) showed drug entrapment efficiency of 90.92 ± 2.34%, cumulative drug release of 41.65 ± 3.97% after 7 h in simulated gastric fluid (pH 1.2), and well buoyancy over 8 h in simulated gastric fluid (pH 1.2) with 5.20 min buoyant lag-time. The in vitro drug release from these buoyant beads followed Korsmeyer–Peppas model (R2 = 0.9866–0.9995) with anomalous (non-Fickian) diffusion drug release mechanism. These new sterculia gum–alginate buoyant beads containing aceclofenac were also characterized using SEM, FTIR, and P-XRD analysis.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Buoyant beads of aceclofenac were prepared by ionotropic emulsion-gelation. ► Sodium alginate, sterculia gum, and liquid paraffin were used as excipients. ► Effect of variables on bead properties was optimized by 32 factorial design. ► Optimized beads showed high drug entrapment and sustained in vitro drug release. ► These beads showed well buoyancy over 7 h in simulated gastric fluid (pH 1.2).

Related Topics
Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry
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