Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6001040 | Thrombosis Research | 2015 | 7 Pages |
Abstract
Using a new detection cytofluorimetric approach, we demonstrated that the AnnV-negative MPs, underestimated/or excluded in the previous studies, are a large subset of circulating MPs. Also, the levels of MPs in the plasma of aPL positive subjects indicate a state of cellular activation, which is much more pronounced in patients with APS compared to aPL carriers. Moreover, the preliminary data of our pilot study suggest that the evaluation of circulating MPs, in particular PMPs and EMPs, could be used as a surrogate biomarker for platelet and vascular damage monitoring and, if confirmed in a more numerous cohort of patients, it could be used as a prognostic factor to identify aPL positive subjects at higher risk of developing thrombosis.
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Authors
Elena Niccolai, Danilo Squatrito, Giacomo Emmi, Elena Silvestri, Lorenzo Emmi, Lucia Ciucciarelli, Federica Ricci, Daniele Manganaro, Amedeo Amedei, Domenico Prisco,