| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6001064 | Thrombosis Research | 2015 | 8 Pages |
Abstract
N2 can improve the motor function, learning and memory ability in MCAO/R rats while reducing the infarct volume. N2 can inhibit TXA2 formation but promote PGI2, and can inhibit platelet aggregation induced by U46619 and ADP. Further, N2 inhibits thrombosis with a minor adverse effect of bleeding than Clopidogrel. In conclusion, N2 can produce the protective effect on MCAO/R brain injury through inhibiting TXA2 formation, platelet aggregation and thrombosis.
Keywords
U46619TxA2PPPTTCPLA2MCAO/RADPTXB2MCAOPrPLTS2,3,5-triphenyl-tetrazolium chloride6-keto-PGF1α6-keto-prostaglandin F1αadenosine diphosphatephospholipase A2Arachidonic acidmiddle cerebral artery occlusion/reperfusionmiddle cerebral artery occlusionPlatelet aggregationthromboxane B2Thromboxane A2Enzyme-linked immunosorbent assayELISAIschemic strokeLeukotrienesplatelet-poor plasmaplatelet-rich plasma
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Authors
Lijian Yang, Xi Chen, Siqi Wang, Yuxiang Fei, Ding Wang, Yunman Li, Guangwei He, Qiang Wu, Shaoxing Chu, Weirong Fang,