Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6001106 | Thrombosis Research | 2014 | 28 Pages |
Abstract
Ex vivo supplementation with fibrinogen or platelet concentrate resulted in significantly shortened clotting time and improved clot strength in a dose-dependent manner. Combination of fibrinogen and platelets further improved the clotting time and strength. Platelet supplementation enhanced platelet aggregation in a dose-dependent manner while fibrinogen had no or reducing effect. Combining fibrinogen and platelets improved platelet aggregation less than the use of platelets alone. In conclusion, combined platelet and fibrinogen supplementation of blood samples from cardiac surgery patients had an additive effect on clot formation compared to the individual components, but it resulted in less platelet aggregation than with platelet supplementation alone. These results may have implications for clinical transfusion protocols.
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Authors
Caroline Shams Hakimi, Inger Fagerberg Blixter, Emma C. Hansson, Camilla Hesse, HÃ¥kan Wallén, Anders Jeppsson,