Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6002539 | Thrombosis Research | 2012 | 7 Pages |
Abstract
Bleeding and thrombosis are the ultimate clinical outcomes of aberrations in the haemostatic process. Haemostasis prevents excessive blood loss due to the effort of various compartments like the vasculature, blood cells, coagulation and fibrinolysis. The complexity of all processes involved makes the diagnosis of aberrations difficult, cumbersome and expensive. A single assay to detect any factor disturbing this haemostatic balance with high sensitivity and specificity would be of great value, especially if the outcome of this assay correlates well with clinical outcome. Despite years of research, such an assay is not yet available; however, some interesting candidates are under development and combine the effects of various compartments. This review describes the development of global haemostasis assays and summarizes the current state of the art of these haemostasis assays covering thrombin and plasmin generation, turbidity and thromboelastography/thromboelastometry. Finally, we discuss the applicability of global assays in clinical practice and we provide a future perspective on the ongoing development of automation and miniaturisation as it is our belief that these developments will benefit the standardization of global haemostasis assays.
Keywords
ETPTEGFVIIIFVIITAFIA10UFHLMWHPAI-1A20FLTCLTFXIIAPCAmCFXIHMWKFVIIaPOCtPATFPIGFCTMAAPTTOHPmaximal amplitudeECLTα2MAUCKcatnHAROTEMFXIIIα2-macroglobulinantithrombinContinuous measurementTATThromboelastographyRotational thromboelastometryThrombomodulinthrombin-antithrombinThrombin Generation TestThrombin generationFIXWhole bloodMichaelis-Menten constantactivated partial thromboplastin timeClotting timeeuglobulin clot lysis timeclot lysis timeActivated factor VIITissue factorFactor VIIIFactor IXFactor VFactor VIIFactor XFactor XIFactor XIIFactor XIIITissue-type plasminogen activatorEnzyme activityFibrinolysisfibrin degradation productsarea under the curvePlasminogen activator inhibitor-1Thrombin activatable fibrinolysis inhibitorTissue factor pathway inhibitorHydrolysis rateHaemostasisHemophilia Ahemophilia Bunfractionated heparinendogenous thrombin potentialActivated protein CTurbidityhigh molecular weight kininogen
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Authors
Mark van Geffen, Waander L. van Heerde,