Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution

Article ID	Journal	Published Year	Pages	File Type
6002775	Thrombosis Research	2011	6 Pages	PDF

Abstract

HIF1Î± levels in vein wall are not affected by thrombosis and it appears that the angiogenic drive in the vein surrounding resolving thrombus is regulated independently of HIF1Î±. Stimulating HIF1Î± levels in the vein wall leads to an increased angiogenic drive and promotes vein recanalisation and thrombus resolution.

Keywords

IVC PlGF HIF1α l-Mimosine Angiogenesis hypoxia-inducible factor 1α placental growth factor Hypoxia-inducible factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Hypoxia Inferior vena cava

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Preview

Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution

Authors

Colin E. Evans, Julia Humphries, Matthew Waltham, Prakash Saha, Katherine Mattock, Ashish Patel, Anwar Ahmad, Ashar Wadoodi, Bijan Modarai, Kevin Burnand, Alberto Smith,