Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection

Article ID	Journal	Published Year	Pages	File Type
6003311	Thrombosis Research	2012	5 Pages	PDF

Abstract

Polymorphism of PAI-1, a major regulator of fibrinolysis, has an adverse impact on the outcome of kidney function in PUUV-HFRS. Platelet collagen receptor GP Ia polymorphism associates with lower platelet count.

Keywords

vWF HFRS CBC IL-6 Human leukocyte antigen HLA Coagulation interleukin-6 PAI plasminogen activator inhibitor Hemorrhagic fever with renal syndrome complete blood count Von Willebrand factor Fibrinolysis HPA nephropathia epidemica Hantavirus Puumala virus C-reactive protein CRP Platelet Polymorphism Single nucleotide polymorphism PUUV SNP Glycoprotein

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Preview

Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection

Authors

Outi Laine, Lotta Joutsi-Korhonen, Satu Mäkelä, Jussi Mikkelsson, Tanja Pessi, Sari Tuomisto, Heini Huhtala, Daniel Libraty, Antti Vaheri, Pekka Karhunen, Jukka Mustonen,