Peptide LSARLAF induces integrin Î²3 dependent outside-in signaling in platelets

Article ID	Journal	Published Year	Pages	File Type
6003464	Thrombosis Research	2012	7 Pages	PDF

Abstract

LSA-induced platelet activation is Î²3 dependent, and signaling molecules Src, FcRÎ³-chain, SLP-76 and LAT play crucial roles in LSA-induced Î²3 mediated signaling.

Keywords

ITAM Fc receptor γ-chain SH2 domain-containing leukocyte protein of 76 kDa Arg-Gly-Asp-Ser Outside-in signaling SLP-76 PLCγ2 PBS TxA2 SRC RGDS BSA bovine serum albumin integrin αIIbβ3 Syk Thromboxane A2 LAT spleen tyrosine kinase Phosphate buffered saline Linker for activation of T cells immunoreceptor tyrosine-based activation motif

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Peptide LSARLAF induces integrin Î²3 dependent outside-in signaling in platelets

Authors

Haixia Niu, Zhenlu Xu, Ding Li, Lin Zhang, Kemin Wang, Donald B. Taylor, Junling Liu, T. Kent Gartner,