| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6004751 | Autonomic Neuroscience | 2009 | 6 Pages |
Abstract
Deducted interpretations from our experimental approach suggest that Ang II inhibits directly (via AT1 receptors) and indirectly (via sympathostimulator pathway) t-PA mRNA synthesis. It seems unable to influence directly PAI-1 mRNA, but stimulates indirectly PAI-1 mRNA synthesis. Ang II stimulates directly (via AT1 receptors) and indirectly (via sympathostimulator pathway) MMPs synthesis at both transcriptional and protein levels. The enzymatic activity of MMPs does not seem to be influenced directly by Ang II but it could be stimulated indirectly (via sympathostimulator pathway).
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Authors
Houcine Dab, Rafik Hachani, Wassim Hodroj, Mohsen Sakly, Giampiero Bricca, Kamel Kacem,