| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6005476 | Brain Stimulation | 2015 | 30 Pages |
Abstract
Forniceal DBS triggers hippocampal activity and rapidly modulate the expression of neurotrophic factors and markers of synaptic plasticity known to play key roles in memory processing. The clinical effects of DBS of the fornix may, in part, be mediated by producing changes in the expression of these proteins.
Keywords
DBSGDNFAPPhsp70STNANTcFosAβGAP-43Anterior nucleus of the thalamusBDNFβ-Amyloidmild cognitive impairmentAlzheimer's diseaseParkinson's diseasephosphorylated taudeep brain stimulationlong-term potentiationLTPgrowth associated protein 43pTauVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)glial cell-line derived neurotrophic factorBrain-derived neurotrophic factorNTFs, Neurotrophic factorsfornixEntorhinal cortexCSFCerebrospinal fluidSubthalamic nucleusMCIHippocampusheat shock protein 70amyloid precursor proteinSynaptic plasticityCHiP
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Authors
Elise Gondard, Hien N. Chau, Amandeep Mann, Travis S. Tierney, Clement Hamani, Suneil K. Kalia, Andres M. Lozano,