| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6006260 | Brain Stimulation | 2014 | 5 Pages |
BackgroundSinusoidal transcranial alternating current stimulation (tACS) at 5Â kHz applied for 10Â min at 1Â mA intensity over the hand area of the primary motor cortex (M1) results in sustained changes in cortical excitability as previously demonstrated.ObjectiveHere we have assessed safety aspects of this stimulation method by measuring neuron-specific enolase (NSE) levels, examining electroencephalogram (EEG) traces and analyzing anatomical data by using magnetic resonance imaging (MRI).MethodsAltogether 18 healthy volunteers participated in the study. tACS was applied at 5Â kHz for a duration of 10Â min over the left M1 at an intensity of 1Â mA.ResultsAfter stimulation no significant changes were detected in NSE levels, no structural alterations were observed in the anatomical scans and no pathological changes were found in the EEG recordings.ConclusionsOur data imply that the application of tACS is safe at least within these parameters and with these applied protocols.
