| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 600657 | Colloids and Surfaces B: Biointerfaces | 2012 | 7 Pages |
Multi-walled carbon nanotubes (MWCNTs) were first functionalized by arginine and lysine under microwave radiation. Surface functionalization was confirmed by Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and transmission electron microscopy (TEM). After the MWCNTs were functionalized by arginine and lysine, the antibacterial activity of all treated samples was increased significantly against all bacteria that were tested. Based on the observed minimum inhibitory concentration and radial diffusion assay, the sequence of antibacterial activity was MWCNTs-arginine > MWCNTs-lysine > pristine MWCNTs. The functionalized MWCNTs were especially effective against gram-negative bacteria (e.g., Escherichia coli and Salmonella typhimurium). Interestingly, the MWCNT samples were effective against the resistant strain Staphylococcos aureus. The enhanced antibacterial activity was attributed to electrostatic adsorption of bacteria membrane due to positive charges of the functional groups on MWCNTs surface. Since MWCNTs have lower cytotoxicity than single-walled carbon nanotubes, their functionalization with cationic amino acids could be a beneficial approach in the disinfection industry.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► MWCNTs functionalized with amino acids by an environmental-friendly microwave method. ► RDA and MIC results suggest enhanced antibacterial activity of functionalized MWCNTs. ► The antibacterial activity enhancement was more noticeable for MWCNTs-Arg. ► The functionalized MWCNTs exhibit more activity against the gram-negative bacteria.
