Design and evaluation of polymer coated carvedilol loaded solid lipid nanoparticles to improve the oral bioavailability: A novel strategy to avoid intraduodenal administration

Article ID	Journal	Published Year	Pages	File Type
600739	Colloids and Surfaces B: Biointerfaces	2012	9 Pages	PDF

Abstract

âº We designed MCC-coated carvedilol loaded SLN to protect SLN from gastric milieu. âº Improved bioavailability with MCC coated-SLN (oral) compared to uncoated SLN (oral). âº No difference in bioavailability between MCC-SLN (oral) and uncoated SLN (duodenal). âº Clinically inappropriate duodenal administration can be avoided with MCC-SLN (oral).

Keywords

N-carboxymethyl chitosan Stearylamine Entrapment efficiency Bioavailability Solid lipid nanoparticles carvedilol

Related Topics

Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry

Preview

Design and evaluation of polymer coated carvedilol loaded solid lipid nanoparticles to improve the oral bioavailability: A novel strategy to avoid intraduodenal administration

Authors

Vinay Kumar Venishetty, Raghavendra Chede, Rojarani Komuravelli, Laxminarayana Adepu, Ramakrishna Sistla, Prakash V. Diwan,