Discovering EEG resting state alterations of semantic dementia

•First evidence of altered EEG resting state in semantic dementia.•Topographical comparison of resting state EEG microstates between semantic dementia, Alzheimer's disease, and healthy elderlies.•Altered microstate class found in semantic dementia is related with decreased MMSE scores.

ObjectiveDiagnosis of semantic dementia relies on cost-intensive MRI or PET, although resting EEG markers of other dementias have been reported. Yet the view still holds that resting EEG in patients with semantic dementia is normal. However, studies using increasingly sophisticated EEG analysis methods have demonstrated that slightest alterations of functional brain states can be detected.MethodsWe analyzed the common four resting EEG microstates (A, B, C, and D) of 8 patients with semantic dementia in comparison with 8 healthy controls and 8 patients with Alzheimer's disease.ResultsTopographical differences between the groups were found in microstate classes B and C, while microstate classes A and D were comparable. The data showed that the semantic dementia group had a peculiar microstate E, but the commonly found microstate C was lacking. Furthermore, the presence of microstate E was significantly correlated with lower MMSE and language scores.ConclusionAlterations in resting EEG can be found in semantic dementia. Topographical shifts in microstate C might be related to semantic memory deficits.SignificanceThis is the first study that discovered resting state EEG abnormality in semantic dementia. The notion that resting EEG in this dementia subtype is normal has to be revised.