| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 600754 | Colloids and Surfaces B: Biointerfaces | 2012 | 6 Pages |
Abstract
⺠N3-O-toluyl-fluorouracil (TFu) was synthesized as a new and potential antitumor prodrug of 5-fluorouracil. ⺠A nanoparticles-in-microparticles delivery system (NiMS) for TFu as a practical preparation was prepared. ⺠The in vitro release properties of TFu from NiMS were fit diffusion controlled drug release and matrix dissolution dual mechanism. ⺠The TFu-NiMS were valued to develop as a practical preparation for oral or i.v. administration.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Weitong Sun, Na Zhang, Xu Li,