| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 600764 | Colloids and Surfaces B: Biointerfaces | 2012 | 6 Pages |
Abstract
⺠Potential use of well known antimalarial drug chloroquine in cancer therapy. ⺠Designing of chloroquine-gold nanoparticle (GNP-Chl) nanoconjugates for cancer therapeutics. ⺠The release of chloroquine from GNP-Chl at a lower pH suggests lysosomal/endosomal uptake of chloroquine. ⺠GNP-Chl exhibited concentration-dependent cytotoxicity in MCF-7 breast cancer cells. ⺠Autophagy is likely the cause of GNP-Chl-induced necrotic cell death.
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Authors
Prachi Joshi, Soumyananda Chakraborti, Jaime E. Ramirez-Vick, Z.A. Ansari, Virendra Shanker, Pinak Chakrabarti, Surinder P. Singh,