Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6010361 | Epilepsy & Behavior | 2015 | 5 Pages |
Abstract
Experiencing early-life stress has been considered as a potent risk factor for the development of many of brain disorders, including seizures. Intervening mechanisms through which neonatal maternal separation (MS) alters the seizure susceptibility in adulthood have not been well studied. In the current study, by applying 180Â min of MS stress (PND 2-14), we determined the seizure susceptibility and considered the role of the opioid system. Maternal separation increased the seizure threshold, and administration of anticonvulsant/proconvulsant doses of morphine (1 and 30Â mg/kg, respectively) reversed the impact of MS. Using tail flick and hot plate tests, we exposed animals to 30Â min Restraint stress (RS) and found that MS decreased the pain threshold, suggesting the hyporesponsiveness of the opioid system. These results supported the abnormal seizure activity observed in the MS mice and suggested that abnormalities in the opioid system following MS alter seizure susceptibility in later life.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Hossein Amini-Khoei, Shayan Amiri, Armin Shirzadian, Arya Haj-Mirzaian, Sakineh Alijanpour, Maryam Rahimi-Balaei, Ali Mohammadi-Asl, Mahsa Hassanipour, Shahram Ejtemaie Mehr, Ahmad Reza Dehpour,