| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 601075 | Colloids and Surfaces B: Biointerfaces | 2011 | 6 Pages |
The purpose of this study was to fabricate porous poly(lactide-co-glycolide) (PLGA) microparticles for efficient pulmonary deposition and increased therapeutic duration of the antioxidant anthocyanin (ATH). These microparticles were prepared by a water-in-oil-in-water (W1/O/W2) multi-emulsion method with vaporizing ammonium bicarbonate (AB) as a porogen and starch as a viscous additive. High porosity achieved by the decomposition reaction of AB to the base of ammonia, carbon dioxide, and water vapor at 50 °C enabled efficient deposition of ATH throughout the entire lung in BALB/c mice. In addition, the porous microparticles incorporating starch showed sustained ATH release characteristics (up to 5 days) and protracted antioxidant activity (up to 5 days) for 2,2-diphenyl-1-pikryl-hydrazyl (DPPH) radicals, which was comparable to that of the porous microparticles without starch which completely released ATH in 2 h. Furthermore, these porous microparticles incorporating starch led to longer ATH residence (up to 20 days) in in vivo lung epithelium. We believe that this system has great pharmaceutical potential as a long-acting antioxidant for continuously relieving oxidative stress in pulmonary diseases like chronic obstructive pulmonary disease (COPD).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We fabricated porous poly(lactide-co-glycolide) microparticles for increased therapeutic duration of antioxidant. ► These microparticles led to longer antioxidant residence (∼20 days) in in vivo lung epithelium. ► This system exhibited great pharmaceutical potential as a long-acting antioxidant for treating pulmonary diseases.
