| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 601083 | Colloids and Surfaces B: Biointerfaces | 2011 | 6 Pages |
Bi-soft segmented poly(ester urethane urea) microparticles were prepared and characterized aiming a biomedical application. Two different formulations were developed, using poly(propylene glycol), tolylene 2,4-diisocyanate terminated pre-polymer (TDI) and poly(propylene oxide)-based tri-isocyanated terminated pre-polymer (TI). A second soft segment was included due to poly(ɛ-caprolactone) diol (PCL). Infrared spectroscopy, used to study the polymeric structure, namely its H-bonding properties, revealed a slightly higher degree of phase separation in TDI-microparticles. TI-microparticles presented slower rate of hydrolytic degradation, and, accordingly, fairly low toxic effect against macrophages. These new formulations are good candidates as non-biodegradable biomedical systems.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Phase separation between soft and hard segments was observed in both matrices. ► Microparticles presented low rate of hydrolytic degradation. ► Microparticles caused low toxic effects in mouse peritoneal macrophages.
