| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 601087 | Colloids and Surfaces B: Biointerfaces | 2011 | 7 Pages |
Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► PEI-capped silver nanoparticles (PEI-AgNPs) were synthesized with NaBH4. ► The amounts of PEI and NaBH4 is important to yield the small and stable AgNPs. ► The PEI-AgNPs and even PEI had a good antimicrobial activity and cytotoxic effect.
