| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 601119 | Colloids and Surfaces B: Biointerfaces | 2011 | 7 Pages |
Amphiphilic polymers for dual drug delivery have been a focus of research in recent years. We have previously developed and characterized Lauroyl sulphated chitosan (LSCS). Here biological characterizations like mucoadhesion, cytotoxicity, calcium binding, tight junction opening and enzymatic degradation studies were performed to understand its applicability. In vitro drug release properties of both hydrophilic insulin and hydrophobic curcumin were carried out. The biological activity and stability of released insulin were also studied. The stability studies of encapsulated curcumin and uptake studies have also been carried out. LSCS showed strong mucoadhesion and 100% of non-toxicity. LSCS could transiently open tight junctions between Caco-2 cells and thus increase the paracellular permeability. LSCS enhanced calcium binding properties and decreased enzymatic degradation rate retaining insulin activity. LSCS could protect curcumin from photodegradation and could also enter into the cells. From release studies, LSCS was found to be a suitable candidate for both drugs.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Amphiphilic polymers have been focused for the recent years for both hydrophobic and hydrophilic drug delivery. ► The hydrophobic core provides a loading space for water-insoluble drugs whereas the hydrophilic shell protects water soluble drugs. ► We have studied the Lauroyl sulphated chitosan (LSCS) the comparative release properties of both the insulin and curcumin drugs from the matrix. ► We have developed a mucoadhesive LSCS submicroparticles and it was found that successful encapsulation of both insulin and curcumin as per the application is possible.
