| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 601146 | Colloids and Surfaces B: Biointerfaces | 2011 | 7 Pages |
Drug–phospholipid lipid nanoparticles (DPLNs) are prepared by incorporating drug–phospholipid complexes (DPCs) with a liquid lipid. DPLNs demonstrated interesting properties including increased encapsulation capacity, improved stability and controlled drug release profile. A comprehensive characterization of DPLNs was presented and then a schematic model was suggested according to the characterization results. Transmission electron microscopy and scanning electron microscope measurements showed the morphology of DPLNs. X-ray diffraction exhibited a predominantly amorphous structure for DPCs and totally amorphous for DPLNs. Laser confocal scanning microscopy revealed the relative position of DPCs and liquid lipid, showing that DPLNs formed a homogeneous system. Fluorescence spectra and electron spin resonance further confirmed the chemical environment inside the DPLNs in a non-invasive way.
Graphical abstractA novel nanoparticle is constituted of amorphous lipids, yielding high drug loading, excellent encapsulation effect and impressive stable capacity. The micro-structure is totally amorphous homogeneous.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► A novel nanoparticle is constituted of amorphous lipids. ► The micro-structure is totally amorphous homogeneous. ► This drug delivery system is provided with high drug loading, excellent encapsulation effect and impressive stable capacity. ► Release of drug in this system fits erosion-controlled mechanism.
