Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6012268 | Epilepsy & Behavior | 2014 | 6 Pages |
Abstract
In the maximal PTZ model, DHA significantly increased seizure latency by approximately 3-fold as compared to vehicle-injected animals. This increase in seizure latency was associated with an increase in serum unesterified DHA. Total brain DHA and brain unesterified DHA concentrations, however, did not differ significantly in the treatment and control groups. An increase in serum unesterified DHA concentration reflecting increased flux of DHA to the brain appears to explain changes in seizure threshold, independent of changes in brain DHA concentrations.
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Authors
Marc-Olivier Trépanier, Joonbum Lim, Terence K.Y. Lai, Hye Jin Cho, Anthony F. Domenichiello, Chuck T. Chen, Ameer Y. Taha, Richard P. Bazinet, W.M. Burnham,