Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

► Calbindin expression in granule cells of the dentate gyrus is reduced in epilepsy. ► We correlated calbindin expression in the granule cells and memory of epilepsy patients. ► Regression was found between verbal memory function and loss of calbindin expression. ► Regression is significant in epilepsy cases without hippocampal sclerosis. ► Loss of calbindin in the granule cells contributes to patients' memory impairment.