Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception

► γ-Aminobutyric acid-mediated Cl- influx blockade causes tonic-clonic epileptic seizures. ► Tonic-clonic convulsions are followed by antinociception. ► The cholinergic system and nucleus raphe magnus modulate pain after seizures. ► Cholinergic inputs to the nucleus raphe magnus modulate postictal antinociception. ► Nucleus raphe magnus muscarinic and nicotinic receptors are involved in both interictal and postictal analgesia.