| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6013950 | Epilepsy & Behavior | 2011 | 6 Pages |
Abstract
⺠Rats exposed to the flurothyl model of early-life seizures showed impaired behavioral flexibility in later adulthood. ⺠Early-life seizures increased the thickness and cell number of the prefrontal cortex in these rats. ⺠Increased prefrontal cortex thickness correlated with impaired behavioral flexibility. ⺠We suggest that behavioral disorders after early-life seizures may be related to fixed alterations in the prefrontal cortex.
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Authors
Jonathan K. Kleen, Alexandre Sesqué, Edie X. Wu, Forrest A. Miller, Amanda E. Hernan, Gregory L. Holmes, Rod C. Scott,