| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6014084 | Epilepsy & Behavior | 2011 | 7 Pages |
Abstract
⺠Pretreatment of rats with the ethyl acetate fraction from Platonia insignis increases ambulation and rearing. ⺠Pretreatment of rats with the ethyl acetate fraction before treatment with 400 mg/kg pilocarpine significantly reduces lipid peroxidation and nitrite levels. ⺠Pretreatment of rats with the ethyl acetate fraction before before treatment with 400 mg/kg pilocarpine significantly increases superoxide dismutase and catalase activities in rat striatum. ⺠The ethyl acetate fraction did not increase the latency to development of convulsions induced with pentylenetetrazole and picrotoxin at the doses tested. ⺠The ethyl acetate fraction from Platonia insignis exerts a neuroprotective effect against striatal oxidative stress.
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Authors
Joaquim Soares Júnior, Antonia Amanda C. de Almeida, Adriana da Rocha Tomé, Antonia Maria das Graças Lopes Citó, Jenifer Saffi, Rivelilson Mendes de Freitas,