Premenstrual dysphoric disorder in women with epilepsy: Relationships to potential epileptic, antiepileptic drug, and reproductive endocrine factors

► Antiepileptic drug levels, ovulatory status, and hormones influence premenstrual dysphoric disorder in women with epilepsy. ► Premenstrual dysphoric disorder severity is greater with right- than left sided epilepsy and with temporal foci. ► Premenstrual dysphoric disorder severity scores are greater with anovulatory cycles. ► Scores correlate with progesterone levels and estradiol/progesterone ratios. ► Mood scores favor carbamazepine and lamotrigine over levetiracetam.