| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6014417 | Epilepsy & Behavior | 2011 | 9 Pages |
There are increasing data on the influence of seizures on neurogenesis in the adult brain. However, data on cell proliferation and differentiation during the early stages of kindling are scarce. We have used pentylenetetrazole (PTZ)-induced kindling to investigate the temporal profile of cytogenesis in the germinative zones of adult rat brain. For comparison, we also used a single PTZ-induced generalized tonic-clonic seizure. During kindling development, the density of 5-bromo-2'-deoxyuridine-positive cells demonstrated similar changes in all germinative zones: a dramatic decrease after the first subthreshold PTZ injection, and a gradual increase to the control level following repeated PTZ administration. On the contrary, a single PTZ-induced generalized tonic-clonic seizure was followed by an increase in the number of proliferating cells in both the dentate gyrus and the subventricular zone. These results may indicate the existence of global mechanisms affecting cellular proliferation in adult brain during seizures. Different temporal profiles of neuronal damage and proliferation changes suggest that neurodegeneration is unlikely to be a global proliferation-regulating factor. The data may contribute to better understanding of the initial phase of kindling development and epileptogenesis.
⺠Injection of subthreshold pentylenetetrazole into adult rats induces a decrease in brain cell proliferation. ⺠Pentylenetetrazole kindling is associated with a gradual increase in the proliferation rate to normal. ⺠Pentylenetetrazole-induced status epilepticus results in an increase in the proliferation rate. ⺠Changes in cell proliferation were similar in the subgranular and subventricular zones.
