| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6014431 | Epilepsy & Behavior | 2011 | 6 Pages |
Abstract
⺠Lacosamide is thought to exert its antiepileptic effect by enhancing sodium channel slow inactivation. ⺠The drug was effective and well tolerated when used with traditional sodium blockers as well as antiepileptic drugs with other mechanisms. ⺠Seizure freedom was more likely when lacosamide was used as a first add-on than with a later treatment schedule. ⺠Patients on sodium valproate were more likely to stop lacosamide (most with side effects) than those taking other antiepileptic drugs. ⺠Results suggest that lacosamide's pharmacological effect differs from that of other antiepileptic drugs that influence sodium channel fast inactivation.
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Authors
Linda J. Stephen, Kevin Kelly, Pamela Parker, Martin J. Brodie,