| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6014894 | Epilepsy & Behavior | 2011 | 4 Pages |
Abstract
⺠Combining lacosamide with other anti-sodium channel-blocking antiepileptic drugs can lead to toxicity. ⺠Up to 17% of people may be affected by this pharmacodynamic interaction. ⺠The slow inactivated state might change the affinity of sodium channels for antiepileptic drugs. ⺠Reduction of concomitant anti-sodium channel-blocking antiepileptic drugs during lacosamide titration.
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Authors
Jan Novy, Philip N. Patsalos, Josemir W. Sander, Sanjay M. Sisodiya,