Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6015019 | Epilepsy Research | 2016 | 9 Pages |
Abstract
Significance: Pharmacokinetics of perampanel are similar in adolescents to adults. Increasing perampanel exposure reduces seizure frequency and increases probability of being a responder regardless of concomitant inducers. The lack of relationship between perampanel exposure and cognitive function suggests a benign cognitive profile for this AED in adolescents. We await results from long-term exposure.
Keywords
uridine 5′-diphospho-glucuronosyltransferaseAEDCDRCyPUGTAMPAα-amino-3-hydroxyl-5-methyl-4-isoxazole-propionateIIVCL/FPK/PDPartial-onset seizuresApparent clearanceInter-individual variabilityapparent volume of distributionantiepileptic drugCNSCytochrome P450central nervous systemCognitionPharmacodynamicspharmacokineticPharmacokineticsExposure-responseAdolescentsPerampanelposAMPA receptor
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Authors
Vicente Villanueva, Oneeb Majid, Charcrin Nabangchang, Haichen Yang, Antonio Laurenza, Jim Ferry, Ziad Hussein,