Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
601530 | Colloids and Surfaces B: Biointerfaces | 2010 | 4 Pages |
Abstract
More and more researchers are interested in DNA binders with sequence selectivity which may be developed to potential drugs. In this paper, we mainly review the compounds that selectively bind to special bases or sequences such as AT and GC-rich sequences. The selective binding of them to DNA sequences could affect the interactions of transcription factors with their target sequences in DNA. Furthermore, the design and effectiveness of sequence-selective DNA binding drugs are discussed. At last we put forward the some current challenges and solution in developing targeting anticancer drugs binding to specific oncogene.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Bochu Wang, Jun Tan, Liancai Zhu,