Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6015728 | Epilepsy Research | 2013 | 7 Pages |
Abstract
Low-frequency stimulation (LFS) is emerging as a new option for the treatment of intractable epilepsy. The stimulation duration may influence the anti-epileptic effect of LFS but is poorly studied. The present study was designed to evaluate the anti-epileptic effect of focal LFS with different stimulation duration on amygdaloid-kindling seizures in rats. We found 15 and 30Â min but not 1 or 5Â min LFS delivered immediately after the kindling stimulation slowed the progression of behavioral seizure stages and reduced mean afterdischarge duration (ADD) during kindling acquisition. In fully kindled animals, 15 and 30Â min rather than 1 and 5Â min LFS decreased the incidence of generalized seizures and the average seizure stage as well as shortened the cumulative generalized seizure duration (GSD). Meanwhile, EEG analysis showed 15 and 30Â min LFS specifically lowered the power in delta band. However, if 15Â min LFS delivered intermittently by 5Â min interval, it had no suppressing effect on kindling rat. Thus, it is likely that consecutive 15Â min is necessary for LFS to inhibit amygdaloid-kindling seizures in rats, indicating the stimulation duration may be a key fact affecting the clinical effect of LFS on epilepsy.
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Authors
Yang Liu, Yi Wang, Zhenghao Xu, Cenglin Xu, Xiaoying Ying, Shuang Wang, Shihong Zhang, Bo Xiao, Zhong Chen,